Brussels Airlines
flies
5 times a day on weekdays from
Brussels
Zaventem Airport (BRU) to
Milan Malpensa
(MXP) in June 2010 with an BA Avro RJ 85 jet. During the weekend they seem to have only 2 or 3 daily flights.
Alitalia seems to fly up to 3 times a day on weekdays from
Brussels
Zaventem Airport (BRU) to Milan Linate airport (LIN) in June 2010, often with their Airbus A319.
Ryanair
flies from Brussels
South Charleroi
airport (CLR) to Milan Bergamo airport in 2010.
Flighttime between Brussels and milan is around 1 hour 30 minutes.
The distance is only 437 miles or 699 km, but the Alps are between Brussels and Milan.