This park in the city of Rome is 80 hectares in size. Just South of the park and especially the area between the park and the Rome Termini railway station seems to be a very good neighbourhood of Rome, as in 2010 almost all 5-star hotels in the city seems to be concentrated in that area between the park and the station.

The area where this hotels are is Quirinal Hill.

South West of Villa Medici in the Villa Borghese park you will find Piazza di Spagna is also some car free expensive shopping streets.

South East of  Villa Medici in the Villa Borghese park you will find the highest concentration of 5-star hotels in the city. So this is definity a very good neighbourhood. And it's all nearby the Rome Termini railway station, which is you link to the airport  (FCO)